Crystal and molecular structure of V-amylose complexed with ibuprofen

Rectangular V-amylose single crystals were prepared by adding racemic ibuprofen to hot dilute aqueous solutions of native and enzymatically-synthesized amylose. The lamellar thickness increased with increasing degree polymerization amylose reached a plateau at about 7 nm, consistent chain-folding mechanism. CP/MAS NMR spectrum as well base-plane electron powder X-ray diffraction patterns recorded from hydrated specimens similar those complexed propan-2-ol. Amylose was crystallized in an orthorhombic unit cell parameters = 2.824 ± 0.001 b 2.966 c 0.800 nm. A molecular model proposed based on structural analogies the Vpropan-2-ol complex assumptions stoichiometry ibuprofen. would contain four antiparallel 7-fold helices molecules distributed inside between helices.